Genetic engineering of Theileria parva lactate dehydrogenase gene: a new anti-theilerial target
نویسندگان
چکیده
منابع مشابه
Characterization of the Theileria parva sporozoite proteome
East Coast fever is a lymphoproliferative disease caused by the tick-borne protozoan parasite Theileria parva. The sporozoite stage of this parasite, harboured and released from the salivary glands of the tick Rhipicephalus appendiculatus during feeding, invades and establishes infection in bovine lymphocytes. Blocking this initial stage of invasion presents a promising vaccine strategy for con...
متن کاملApproaches to vaccination against Theileria parva and Theileria annulata
Despite having different cell tropism, the pathogenesis and immunobiology of the diseases caused by Theileria parva and Theileria annulata are remarkably similar. Live vaccines have been available for both parasites for over 40 years, but although they provide strong protection, practical disadvantages have limited their widespread application. Efforts to develop alternative vaccines using defi...
متن کاملA rapid and sensitive intracellular flow cytometric assay to identify Theileria parva infection within target cells.
Theileria parva is an intracellular protozoan parasite transmitted by ticks that causes a fatal lymphoproliferative disease of cattle known as East Coast Fever. Vaccination against the disease currently relies on inoculation of the infective sporozoite stage of the parasite and simultaneous treatment with long-acting formulations of oxytetracycline. Sporozoites are maintained as frozen stabilat...
متن کاملGenetic Variation of Choline Dehydrogenase Gene in Idiopathic Male Infertility
Infertility can be caused by an unexplained reduction in semen quality in males who present asnormal on physical examination and endocrine testing. There is some evidence that aberrantmetabolism of micronutrients such as choline may play a causative role in male factorinfertility. Choline is a crucial factor in the regulation of sperm membrane structure andmotility, and this nutrient plays an i...
متن کاملLimited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva
An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions provides high levels of protection, some animals are not protected against challenge with buffalo-de...
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ژورنال
عنوان ژورنال: Pesquisa Veterinária Brasileira
سال: 2018
ISSN: 1678-5150,0100-736X
DOI: 10.1590/1678-5150-pvb-5116